The Bicol Region is located in the southernmost tip of Luzon Island, the largest island in the Philippine archipelago. The total land area of the region is 18,054.3 km2 (6,970.8 sq mi), which or 5.9% of the total land area of the country. Around 69.3% of the total land area is alienable and disposable while the remaining 30.7% is public forest areas.

The region is bounded by Lamon Bay to the north, Pacific Ocean to the east, and Sibuyan Sea and Ragay Gulf to the west. The northernmost province, Camarines Norte, is bordered to the north by the province of Quezon, thereby connecting the region to the rest of Luzon.